Bio-Functionalizing MOF Nanoparticles

A sustainable and eco-friendly ligand for diverse nanoparticles functionalization is reported. The ligand is synthesized through a photochemical reaction between lecithin and cysteine, followed by the addition of mannose, a sugar beneficial for biomedical targeting. The environmental impact of the ligand is assessed through green metrics, demonstrating superior sustainability compared to conventional ligands. The ligand is successfully applied to various nanoparticle platforms, including the MOFs MIL-101(Fe), PCN-222, UiO-66, and iron nanoparticles, highlighting its potential for safer and more effective applications in nanomedicine.

https://pubs.rsc.org/en/content/articlelanding/2024/gc/d4gc03743j