EU4MOFs aims at increasing control and customization over the interplay between (re)activity, selectivity, efficiency and processability of MOF materials to ensure optimal functional properties at these three length scales. EU4MOFs will focus on paving the way towards the development of nano-, meso- and macro-scale high-performing MOF materials for three high-need applications: (cancer) nanomedicine, wastewater treatment and energy storage. To achieve this, manufacturing technologies based on bottom-up synthesis and top-down engineering strategies will be consolidated, and high throughput computational screening and machine learning methods will be integrated to improve structure property predictions and the resulting materials performance. By uniting interdisciplinary researches from the fields of (bio)chemistry, materials engineering, physics, nanomedicine, pharmacy, and computational science, together with industrial partners, EU4MOFs will contribute to substantially advance the current frontiers of MOF materials from the laboratory bench towards industrial-scale, in order to ultimately generate societal impact.